ghetto

The word comes from the name of the Venetian Ghetto, the district where Venice confined its Jewish residents. Where that name itself came from is uncertain — its ultimate source language isn't known for sure.

The facts here don't give a documented shift in meaning, just the borrowing of a place-name into general use for segregated neighborhoods.

Italian has its own form, ghetto, closely tied to the same Venetian origin, but no other confirmed relative is given in the facts.